Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (â)-Sophoranone on CYP2C9 is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (â)-Sophoranone.

Zheng, Yu Fen; Bae, Soo Hyeon; Huang, Zhouchi; Chae, Soon Uk; Jo, Seong Jun; Shim, Hyung Joon; Lee, Chae Bin; Kim, Doyun; Yoo, Hunseung; Bae, Soo Kyung

Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (â)-Sophoranone on CYP2C9 is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (â)-Sophoranone.

Zheng, Yu Fen; Bae, Soo Hyeon; Huang, Zhouchi; Chae, Soon Uk; Jo, Seong Jun; Shim, Hyung Joon; Lee, Chae Bin; Kim, Doyun; Yoo, Hunseung; Bae, Soo Kyung.

Affiliation

Zheng YF; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 639 Longmian Road, Jiangning District, Nanjing, Jiangsu 211198, China.
Bae SH; Q-fitter, Inc., Seoul 06578, Korea.
Huang Z; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University, Korea, Bucheon 14662, Korea.
Chae SU; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University, Korea, Bucheon 14662, Korea.
Jo SJ; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University, Korea, Bucheon 14662, Korea.
Shim HJ; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University, Korea, Bucheon 14662, Korea.
Lee CB; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University, Korea, Bucheon 14662, Korea.
Kim D; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University, Korea, Bucheon 14662, Korea.
Yoo H; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University, Korea, Bucheon 14662, Korea.
Bae SK; Life Science R&D Center, SK Chemicals, 310 Pangyo-ro, Sungnam 13494, Korea.