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Electrically coupled inhibitory interneurons constrain long-range connectivity of cortical networks.
Kraft, Andrew W; Mitra, Anish; Rosenthal, Zachary P; Dosenbach, Nico U F; Bauer, Adam Q; Snyder, Abraham Z; Raichle, Marcus E; Culver, Joseph P; Lee, Jin-Moo.
Affiliation
  • Kraft AW; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Mitra A; Department of Psychiatry, Stanford University, Stanford, CA, USA.
  • Rosenthal ZP; Department of Neurology, Washington University, St. Louis, USA.
  • Dosenbach NUF; Department of Neurology, Washington University, St. Louis, USA; Department of Radiology, Washington University, St. Louis, USA; Department of Biomedical Engineering, Washington University, St. Louis, USA; Department of Program in Occupational Therapy, Washington University, St. Louis, USA.
  • Bauer AQ; Department of Radiology, Washington University, St. Louis, USA.
  • Snyder AZ; Department of Neurology, Washington University, St. Louis, USA; Department of Radiology, Washington University, St. Louis, USA.
  • Raichle ME; Department of Neurology, Washington University, St. Louis, USA; Department of Radiology, Washington University, St. Louis, USA.
  • Culver JP; Department of Radiology, Washington University, St. Louis, USA; Department of Biomedical Engineering, Washington University, St. Louis, USA; Department of Physics, Washington University, St. Louis, USA.
  • Lee JM; Department of Neurology, Washington University, St. Louis, USA; Department of Radiology, Washington University, St. Louis, USA; Department of Biomedical Engineering, Washington University, St. Louis, USA. Electronic address: leejm@wustl.edu.
Neuroimage ; 215: 116810, 2020 07 15.
Article in En | MEDLINE | ID: mdl-32276058
ABSTRACT
Spontaneous infra-slow brain activity (ISA) exhibits a high degree of temporal synchrony, or correlation, between distant brain regions. The spatial organization of ISA synchrony is not explained by anatomical connections alone, suggesting that active neural processes coordinate spontaneous activity. Inhibitory interneurons (IINs) form electrically coupled connections via the gap junction protein connexin 36 (Cx36) and networks of interconnected IINs are known to influence neural synchrony over short distances. However, the role of electrically coupled IIN networks in regulating spontaneous correlation over the entire brain is unknown. In this study, we performed OIS imaging on Cx36-/- mice to examine the role of this gap junction in ISA correlation across the entire cortex. We show that Cx36 deletion increased long-distance intra-hemispheric anti-correlation and inter-hemispheric correlation in spontaneous ISA. This suggests that electrically coupled IIN networks modulate ISA synchrony over long cortical distances.
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Full text: 1 Database: MEDLINE Main subject: Cerebral Cortex / Connexins / Interneurons / Nerve Net / Neural Inhibition Limits: Animals Language: En Year: 2020 Type: Article

Full text: 1 Database: MEDLINE Main subject: Cerebral Cortex / Connexins / Interneurons / Nerve Net / Neural Inhibition Limits: Animals Language: En Year: 2020 Type: Article