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High prevalence of DNA damage repair gene defects and TP53 alterations in men with treatment-naïve metastatic prostate cancer -Results from a prospective pilot study using a 37 gene panel.
Nientiedt, Cathleen; Endris, Volker; Jenzer, Maximilian; Mansour, Josef; Sedehi, Nassim Tawanaie Pour; Pecqueux, Carine; Volckmar, Anna-Lena; Leichsenring, Jonas; Neumann, Olaf; Kirchner, Martina; Hoveida, Shirin; Lantwin, Philippa; Kaltenecker, Katrin; Dieffenbacher, Svenja; Gasch, Claudia; Hofer, Luisa; Franke, Desiree; Tosev, Georgi; Görtz, Magdalena; Schütz, Viktoria; Radtke, Jan-Philipp; Nyarangi-Dix, Joanne; Hatiboglu, Gencay; Simpfendörfer, Tobias; Schönberg, Gita; Isaac, Sanjay; Teber, Dogu; Koerber, Stefan A; Christofi, Georgia; Czink, Elena; Kreuter, Rebecca; Apostolidis, Leonidas; Kratochwil, Clemens; Giesel, Frederik; Haberkorn, Uwe; Debus, Jürgen; Sültmann, Holger; Zschäbitz, Stefanie; Jäger, Dirk; Duensing, Anette; Schirmacher, Peter; Grüllich, Carsten; Hohenfellner, Markus; Stenzinger, Albrecht; Duensing, Stefan.
Affiliation
  • Nientiedt C; Molecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Endris V; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Jenzer M; Molecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Mansour J; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Sedehi NTP; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Pecqueux C; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Volckmar AL; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Leichsenring J; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Neumann O; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Kirchner M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Hoveida S; Molecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Lantwin P; Molecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Kaltenecker K; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Dieffenbacher S; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Gasch C; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Hofer L; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Franke D; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Tosev G; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Görtz M; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Schütz V; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Radtke JP; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Nyarangi-Dix J; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Hatiboglu G; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Simpfendörfer T; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Schönberg G; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Isaac S; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Teber D; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Koerber SA; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
  • Christofi G; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Czink E; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Kreuter R; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Apostolidis L; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Kratochwil C; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Giesel F; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Haberkorn U; Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg; Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Debus J; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
  • Sültmann H; Cancer Genome Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Zschäbitz S; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Jäger D; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Duensing A; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany; Cancer Therapeutics Program and Department of Pathology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Pittsburgh, PA; Precision Oncology of Urological Malignancies, Department of Urology, University Ho
  • Schirmacher P; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Grüllich C; Department of Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.
  • Hohenfellner M; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
  • Stenzinger A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: albrecht.stenzinger@med.uni-heidelberg.de.
  • Duensing S; Molecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany; Department of Urology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: stefan.duensing@med.uni-heidelberg.de.
Urol Oncol ; 38(7): 637.e17-637.e27, 2020 07.
Article in En | MEDLINE | ID: mdl-32280037
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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / DNA Damage / Tumor Suppressor Protein p53 / DNA Repair / Neoplasm Metastasis Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Humans / Male / Middle aged Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / DNA Damage / Tumor Suppressor Protein p53 / DNA Repair / Neoplasm Metastasis Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Humans / Male / Middle aged Language: En Year: 2020 Type: Article