Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation.

Pal, Akos; Asad, Yasmin; Ruddle, Ruth; Henley, Alan T; Swales, Karen; Decordova, Shaun; Eccles, Suzanne A; Collins, Ian; Garrett, Michelle D; De Bono, Johann; Banerji, Udai; Raynaud, Florence I

Pal, Akos; Asad, Yasmin; Ruddle, Ruth; Henley, Alan T; Swales, Karen; Decordova, Shaun; Eccles, Suzanne A; Collins, Ian; Garrett, Michelle D; De Bono, Johann; Banerji, Udai; Raynaud, Florence I.

Affiliation

Pal A; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Asad Y; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Ruddle R; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Henley AT; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Swales K; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Decordova S; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Eccles SA; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Collins I; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Garrett MD; School of Biosciences, University of Kent, Canterbury, UK.
De Bono J; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.
Banerji U; Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK.
Raynaud FI; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.

Metabolomics ; 16(4): 50, 2020 04 13.

Article in En | MEDLINE | ID: mdl-32285223

Subject(s)

2-Hydroxyphenethylamine/analogs & derivatives; Antineoplastic Agents/metabolism; Metabolomics; Nitric Oxide Synthase/antagonists & inhibitors; Protein Kinase Inhibitors/metabolism; Pyrazoles/metabolism; 2-Hydroxyphenethylamine/administration & dosage; 2-Hydroxyphenethylamine/metabolism; 2-Hydroxyphenethylamine/pharmacology; Administration, Oral; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/pharmacology; Biomarkers, Tumor/blood; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Glycogen Synthase Kinase 3 beta/blood; Glycogen Synthase Kinase 3 beta/metabolism; Humans; Mice; Mice, Nude; Neoplasms, Experimental/drug therapy; Neoplasms, Experimental/metabolism; Neoplasms, Experimental/pathology; Nitric Oxide Synthase/metabolism; PC-3 Cells; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/metabolism; Pyrazoles/administration & dosage; Pyrazoles/pharmacology

Key words

ADMA; AT13148; Hypotension; NOS; Targeted metabolomics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Pyrazoles / 2-Hydroxyphenethylamine / Nitric Oxide Synthase / Protein Kinase Inhibitors / Metabolomics / Antineoplastic Agents Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Year: 2020 Type: Article

Fulltext

XML

PubMed Links

Search on Google