Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings.
Clin Kidney J
; 13(2): 261-262, 2020 Apr.
Article
in En
| MEDLINE
| ID: mdl-32296530
ABSTRACT
We report a case of anti-glomerular basement membrane (GBM) disease in association with human leucocyte antigen (HLA) DRB1 1501. A 71-year-old woman presented with oligoanuric acute kidney injury accompanied by high titre anti-GBM antibodies. Renal biopsy revealed a severe crescentic glomerulonephritis. Her brother had presented 6 years earlier with oligoanuric acute kidney injury. He was dual positive for MPO ANCA and anti-GBM antibodies. Renal biopsy was not performed. Both had an absence of pulmonary involvement. Tissue typing confirmed both were heterozygous for HLA DRB1 1501 and DRB1 0403.
Full text:
1
Database:
MEDLINE
Type of study:
Risk_factors_studies
Language:
En
Year:
2020
Type:
Article