Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action.
Br J Haematol
; 189(5): 846-847, 2020 06.
Article
in En
| MEDLINE
| ID: mdl-32304577
ABSTRACT
Emerging evidence shows that severe coronavirus disease 2019 (COVID-19) can be complicated with coagulopathy, namely disseminated intravascular coagulation, which has a rather prothrombotic character with high risk of venous thromboembolism. The incidence of venous thromboembolism among COVID-19 patients in intensive care units appears to be somewhat higher compared to that reported in other studies including such patients with other disease conditions. D-dimer might help in early recognition of these high-risk patients and also predict outcome. Preliminary data show that in patients with severe COVID-19, anticoagulant therapy appears to be associated with lower mortality in the subpopulation meeting sepsis-induced coagulopathy criteria or with markedly elevated d-dimer. Recent recommendations suggest that all hospitalized COVID-19 patients should receive thromboprophylaxis, or full therapeutic-intensity anticoagulation if such an indication is present.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Fibrin Fibrinogen Degradation Products
/
Coronavirus Infections
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Venous Thromboembolism
/
Pandemics
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Betacoronavirus
/
Anticoagulants
Type of study:
Etiology_studies
/
Guideline
/
Incidence_studies
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Prognostic_studies
/
Risk_factors_studies
Limits:
Female
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Humans
/
Male
Language:
En
Year:
2020
Type:
Article