The amino terminal domain plays an important role in transjunctional voltage-dependent gating kinetics of Cx45 gap junctions.

Santos-Miranda, Artur; Chen, Honghong; Chen, Robert C; Odoko-Ishimoto, Mamiko; Aoyama, Hiroshi; Bai, Donglin

Santos-Miranda, Artur; Chen, Honghong; Chen, Robert C; Odoko-Ishimoto, Mamiko; Aoyama, Hiroshi; Bai, Donglin.

Affiliation

Santos-Miranda A; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
Chen H; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
Chen RC; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
Odoko-Ishimoto M; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Aoyama H; Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Bai D; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada. Electronic address: donglin.bai@schulich.uwo.ca.

J Mol Cell Cardiol ; 143: 71-84, 2020 06.

Article in En | MEDLINE | ID: mdl-32325151

Subject(s)

Connexins/metabolism; Ion Channel Gating; Protein Interaction Domains and Motifs; Action Potentials; Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line; Connexins/chemistry; Gap Junctions/metabolism; Genes, Reporter; Humans; Mice; Models, Molecular; Myocytes, Cardiac/metabolism; Protein Binding; Protein Transport; Structure-Activity Relationship

Key words

Gap junction channel; Gating kinetics; Patch clamp; connexin45

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Full text: 1 Database: MEDLINE Main subject: Ion Channel Gating / Connexins / Protein Interaction Domains and Motifs Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2020 Type: Article

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