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Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases.
Miao, Zhaohua; Jiang, Shanshan; Ding, Mengli; Sun, Siyuan; Ma, Yan; Younis, Muhammad Rizwan; He, Gang; Wang, Jingguo; Lin, Jing; Cao, Zhong; Huang, Peng; Zha, Zhengbao.
Affiliation
  • Miao Z; School of Food and Biological Engineering, Hefei University of Technology; Hefei 230009, P.R. China.
  • Jiang S; Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, P.R. China.
  • Ding M; School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, P.R. China.
  • Sun S; School of Food and Biological Engineering, Hefei University of Technology; Hefei 230009, P.R. China.
  • Ma Y; School of Food and Biological Engineering, Hefei University of Technology; Hefei 230009, P.R. China.
  • Younis MR; Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, P.R. China.
  • He G; Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, P.R. China.
  • Wang J; School of Food and Biological Engineering, Hefei University of Technology; Hefei 230009, P.R. China.
  • Lin J; Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, P.R. China.
  • Cao Z; School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, P.R. China.
  • Huang P; Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, P.R. China.
  • Zha Z; School of Food and Biological Engineering, Hefei University of Technology; Hefei 230009, P.R. China.
Nano Lett ; 20(5): 3079-3089, 2020 05 13.
Article in En | MEDLINE | ID: mdl-32348149
ABSTRACT
Colitis-associated colorectal cancer (CAC), in which chronic inflammation is a well-recognized carcinogen, requires concurrent anti-inflammation and antitumor treatments in the clinic. Herein, we report polyethylene glycol (PEG)-coated (PEGylated) ultrasmall rhodium nanodots (Rh-PEG NDs) can serve as a metallic nanozyme with reactive oxygen and nitrogen species (RONS) scavenging properties as well as photothermal activities for anti-inflammation and antitumor theranostics in colon diseases. Benefiting from multienzyme activities against RONS, Rh-PEG NDs can decrease the levels of pro-inflammatory cytokines (TNF-α, IL-6), resulting in good anti-inflammatory effect on dextran sulfate sodium-induced colitis. By virtue of high photothermal conversion efficiency (48.9%), Rh-PEG NDs demonstrate complete ablation of CT-26 colon tumor without any recurrence. Most importantly, Rh-PEG NDs exhibit good biocompatibility both at the cellular and animal levels. Our findings provide a paradigm to utilize metallic nanozymes for the potential management of colon diseases.
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Full text: 1 Database: MEDLINE Main subject: Rhodium / Colitis / Colonic Neoplasms / Theranostic Nanomedicine / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Rhodium / Colitis / Colonic Neoplasms / Theranostic Nanomedicine / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Year: 2020 Type: Article