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Association between Mental Disorders and Subsequent Medical Conditions.
Momen, Natalie C; Plana-Ripoll, Oleguer; Agerbo, Esben; Benros, Michael E; Børglum, Anders D; Christensen, Maria K; Dalsgaard, Søren; Degenhardt, Louisa; de Jonge, Peter; Debost, Jean-Christophe P G; Fenger-Grøn, Morten; Gunn, Jane M; Iburg, Kim M; Kessing, Lars V; Kessler, Ronald C; Laursen, Thomas M; Lim, Carmen C W; Mors, Ole; Mortensen, Preben B; Musliner, Katherine L; Nordentoft, Merete; Pedersen, Carsten B; Petersen, Liselotte V; Ribe, Anette R; Roest, Annelieke M; Saha, Sukanta; Schork, Andrew J; Scott, Kate M; Sievert, Carson; Sørensen, Holger J; Stedman, Terry J; Vestergaard, Mogens; Vilhjalmsson, Bjarni; Werge, Thomas; Weye, Nanna; Whiteford, Harvey A; Prior, Anders; McGrath, John J.
Affiliation
  • Momen NC; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Plana-Ripoll O; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Agerbo E; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Benros ME; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Børglum AD; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Christensen MK; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Dalsgaard S; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Degenhardt L; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • de Jonge P; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Debost JPG; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Fenger-Grøn M; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Gunn JM; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Iburg KM; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Kessing LV; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Kessler RC; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Laursen TM; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Lim CCW; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Mors O; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Mortensen PB; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Musliner KL; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Nordentoft M; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Pedersen CB; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Petersen LV; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Ribe AR; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Roest AM; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Saha S; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Schork AJ; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Scott KM; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Sievert C; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Sørensen HJ; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Stedman TJ; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Vestergaard M; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Vilhjalmsson B; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Werge T; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Weye N; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Whiteford HA; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • Prior A; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
  • McGrath JJ; From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public
N Engl J Med ; 382(18): 1721-1731, 2020 04 30.
Article in En | MEDLINE | ID: mdl-32348643
ABSTRACT

BACKGROUND:

Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical conditions.

METHODS:

We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016, for a total of 83.9 million person-years. We assessed 10 broad types of mental disorders and 9 broad categories of medical conditions (which encompassed 31 specific conditions). We used Cox regression models to calculate overall hazard ratios and time-dependent hazard ratios for pairs of mental disorders and medical conditions, after adjustment for age, sex, calendar time, and previous mental disorders. Absolute risks were estimated with the use of competing-risks survival analyses.

RESULTS:

A total of 698,874 of 5,940,299 persons (11.8%) were identified as having a mental disorder. The median age of the total population was 32.1 years at entry into the cohort and 48.7 years at the time of the last follow-up. Persons with a mental disorder had a higher risk than those without such disorders with respect to 76 of 90 pairs of mental disorders and medical conditions. The median hazard ratio for an association between a mental disorder and a medical condition was 1.37. The lowest hazard ratio was 0.82 for organic mental disorders and the broad category of cancer (95% confidence interval [CI], 0.80 to 0.84), and the highest was 3.62 for eating disorders and urogenital conditions (95% CI, 3.11 to 4.22). Several specific pairs showed a reduced risk (e.g., schizophrenia and musculoskeletal conditions). Risks varied according to the time since the diagnosis of a mental disorder. The absolute risk of a medical condition within 15 years after a mental disorder was diagnosed varied from 0.6% for a urogenital condition among persons with a developmental disorder to 54.1% for a circulatory disorder among those with an organic mental disorder.

CONCLUSIONS:

Most mental disorders were associated with an increased risk of a subsequent medical condition; hazard ratios ranged from 0.82 to 3.62 and varied according to the time since the diagnosis of the mental disorder. (Funded by the Danish National Research Foundation and others; COMO-GMC ClinicalTrials.gov number, NCT03847753.).
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Full text: 1 Database: MEDLINE Main subject: Disease / Mental Disorders Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Year: 2020 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Disease / Mental Disorders Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Year: 2020 Type: Article