Predictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin.

Ahern, Thomas P; Damkier, Per; Feddersen, Søren; Kjærsgaard, Anders; Lash, Timothy L; Hamilton-Dutoit, Stephen; Lythjohan, Cathrine Bredal; Ejlertsen, Bent; Christiansen, Peer M; Cronin-Fenton, Deirdre P

Ahern, Thomas P; Damkier, Per; Feddersen, Søren; Kjærsgaard, Anders; Lash, Timothy L; Hamilton-Dutoit, Stephen; Lythjohan, Cathrine Bredal; Ejlertsen, Bent; Christiansen, Peer M; Cronin-Fenton, Deirdre P.

Affiliation

Ahern TP; Departments of Surgery and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Damkier P; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Feddersen S; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Kjærsgaard A; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Lash TL; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Hamilton-Dutoit S; Department of Clinical Epidemiology, Aarhus University Hospital/Randers Regional Hospital, Aarhus, Denmark.
Lythjohan CB; Department of Epidemiology, Rollins School of Public Health and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Ejlertsen B; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark.
Christiansen PM; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark.
Cronin-Fenton DP; Danish Breast Cancer Group, Rigshospitalet, Copenhagen, Denmark.

Acta Oncol ; 59(9): 1009-1015, 2020 Sep.

Article in En | MEDLINE | ID: mdl-32351149

Subject(s)

Biomarkers, Tumor/genetics; Breast Neoplasms/therapy; Neoplasm Recurrence, Local/epidemiology; Simvastatin/pharmacology; ATP Binding Cassette Transporter, Subfamily B/genetics; ATP Binding Cassette Transporter, Subfamily B/metabolism; Aged; Aged, 80 and over; Biomarkers, Tumor/metabolism; Breast/pathology; Breast/surgery; Breast Neoplasms/epidemiology; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Case-Control Studies; Cytochrome P-450 CYP3A/genetics; Cytochrome P-450 CYP3A/metabolism; Denmark/epidemiology; Female; Follow-Up Studies; Humans; Liver-Specific Organic Anion Transporter 1/genetics; Liver-Specific Organic Anion Transporter 1/metabolism; Middle Aged; Neoplasm Recurrence, Local/genetics; Neoplasm Recurrence, Local/prevention & control; Pharmacogenomic Testing; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Predictive Value of Tests; Risk Assessment/methods; Simvastatin/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Biomarkers, Tumor / Simvastatin / Neoplasm Recurrence, Local Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Middle aged Country/Region as subject: Europa Language: En Year: 2020 Type: Article

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