Effects of follow-on therapy after denosumab discontinuation in patients with postmenopausal osteoporosis.
Mod Rheumatol
; 31(2): 485-492, 2021 Mar.
Article
in En
| MEDLINE
| ID: mdl-32412351
ABSTRACT
OBJECTIVES:
To clarify the effects of follow-on therapy after denosumab (DMAb) discontinuation.METHODS:
In this retrospective, multicenter study, postmenopausal patients with osteoporosis who were previously treated by oral bisphosphonates (BP) (n = 26) or teriparatide (TPTD) (n = 27) were switched to DMAb (administered 2.6 times), and then discontinued. Patients (73.1 years, T-scores of the lumbar spine [LS] - 2.7 and femoral neck [FN] - 2.2) were switched to either (1) raloxifene (RAL) (n = 13) or BP [(2) weekly or monthly BP (wmBP) (n = 29) or (3) zoledronate (ZOL) (n = 11)], based on each physician's decision (mean interval after final DMAb administration was 7.2 months). Bone mineral density (BMD) at final DMAb administration were set as baseline.RESULTS:
Changes in LS BMD at 1.5 years after final DMAb administration were -2.7% in the RAL, 0.7% in the wmBP, and 1.9% in the ZOL (p = .31 between groups), and in FN BMD were -3.8%, -0.8%, and 1.8%, respectively (p = .02 between the RAL and ZOL; p = .048 between the RAL and BP). Clinical vertebral fracture incidence during 1.5 years after final DMAb administration was 23.1% in the RAL, 3.4% in the wmBP, and 0.0% in the ZOL (p = .048 between the RAL and ZOL; p = .015 between the RAL and BP). No significant differences were observed in these parameters between the wmBP and ZOL.CONCLUSION:
These results may contribute to the selection of adequate follow-on therapy after DMAb discontinuation, although further investigations are required.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Osteoporosis, Postmenopausal
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Bone Density Conservation Agents
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Denosumab
Limits:
Aged
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Female
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Humans
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Middle aged
Language:
En
Year:
2021
Type:
Article