PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.

Xu, Xiaozheng; Hou, Bowen; Fulzele, Amitkumar; Masubuchi, Takeya; Zhao, Yunlong; Wu, Zijun; Hu, Yanyan; Jiang, Yong; Ma, Yanzhe; Wang, Haopeng; Bennett, Eric J; Fu, Guo; Hui, Enfu

Xu, Xiaozheng; Hou, Bowen; Fulzele, Amitkumar; Masubuchi, Takeya; Zhao, Yunlong; Wu, Zijun; Hu, Yanyan; Jiang, Yong; Ma, Yanzhe; Wang, Haopeng; Bennett, Eric J; Fu, Guo; Hui, Enfu.

Affiliation

Xu X; Division of Biological Sciences, University of California San Diego, La Jolla, CA.
Hou B; School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Fulzele A; Division of Biological Sciences, University of California San Diego, La Jolla, CA.
Masubuchi T; Division of Biological Sciences, University of California San Diego, La Jolla, CA.
Zhao Y; Division of Biological Sciences, University of California San Diego, La Jolla, CA.
Wu Z; Division of Biological Sciences, University of California San Diego, La Jolla, CA.
Hu Y; School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Jiang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Ma Y; Division of Biological Sciences, University of California San Diego, La Jolla, CA.
Wang H; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Bennett EJ; Division of Biological Sciences, University of California San Diego, La Jolla, CA.
Fu G; School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Hui E; Division of Biological Sciences, University of California San Diego, La Jolla, CA.

J Cell Biol ; 219(6)2020 06 01.

Article in En | MEDLINE | ID: mdl-32437509

Subject(s)

Cell Proliferation/genetics; Programmed Cell Death 1 Receptor/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism; Receptors, Immunologic/metabolism; T-Lymphocytes/metabolism; Animals; CD3 Complex/genetics; CD3 Complex/metabolism; Cell Proliferation/drug effects; Chromatography, Liquid; Cytokines/metabolism; Fluorescence Resonance Energy Transfer; Gene Knockout Techniques; HEK293 Cells; Humans; Interleukin-2/metabolism; Jurkat Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Programmed Cell Death 1 Receptor/genetics; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 11/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 6/genetics; Receptors, Immunologic/genetics; Recombinant Proteins; Signal Transduction/drug effects; Signal Transduction/genetics; Signal Transduction/immunology; T-Lymphocytes/drug effects; T-Lymphocytes/enzymology; T-Lymphocytes/immunology; Tandem Mass Spectrometry

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Full text: 1 Database: MEDLINE Main subject: Receptors, Immunologic / T-Lymphocytes / Cell Proliferation / Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Programmed Cell Death 1 Receptor Limits: Animals / Humans Language: En Year: 2020 Type: Article

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