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Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib.
Parrott, Neil; Stillhart, Cordula; Lindenberg, Marc; Wagner, Bjoern; Kowalski, Karey; Guerini, Elena; Djebli, Nassim; Meneses-Lorente, Georgina.
Affiliation
  • Parrott N; Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland. neil_john.parrott@roche.com.
  • Stillhart C; Pharmaceutical Research & Development, Formulation & Process Sciences, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Lindenberg M; Pharmaceutical Research & Development, Analytical, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Wagner B; Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Kowalski K; Ignyta, San Diego, California, 92121, USA.
  • Guerini E; Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Djebli N; Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Meneses-Lorente G; Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland.
AAPS J ; 22(4): 78, 2020 05 26.
Article in En | MEDLINE | ID: mdl-32458089
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Full text: 1 Database: MEDLINE Main subject: Benzamides / Food-Drug Interactions / Protein Kinase Inhibitors / Gastric Absorption / Gastric Mucosa / Indazoles / Models, Biological Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Benzamides / Food-Drug Interactions / Protein Kinase Inhibitors / Gastric Absorption / Gastric Mucosa / Indazoles / Models, Biological Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article