Dysfunctional Nurr1 promotes high glucose-induced Müller cell activation by up-regulating the NF-&#954;B/NLRP3 inflammasome axis.

Li, Wendie; Liu, Xiaojuan; Tu, Yuanyuan; Ding, Dongmei; Yi, Quanyong; Sun, Xiaolei; Wang, Yanyan; Wang, Kun; Zhu, Manhui; Mao, Jinghai

Dysfunctional Nurr1 promotes high glucose-induced Müller cell activation by up-regulating the NF-κB/NLRP3 inflammasome axis.

Li, Wendie; Liu, Xiaojuan; Tu, Yuanyuan; Ding, Dongmei; Yi, Quanyong; Sun, Xiaolei; Wang, Yanyan; Wang, Kun; Zhu, Manhui; Mao, Jinghai.

Affiliation

Li W; Department of Ophthalmology, Ningbo Eye Hospital, Ningbo, China.
Liu X; Department of Pathogen Biology, Medical College, Nantong University, Nantong, China.
Tu Y; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China.
Ding D; Department of Ophthalmology, Laizhou City People's Hospital, Yantai, China.
Yi Q; Department of Ophthalmology, Ningbo Eye Hospital, Ningbo, China.
Sun X; Department of Pathogen Biology, Medical College, Nantong University, Nantong, China.
Wang Y; Department of Ophthalmology, Ningbo Eye Hospital, Ningbo, China.
Wang K; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China.
Zhu M; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China. Electronic address: zhumanhuieye@126.com.
Mao J; Department of Ophthalmology, Ningbo Eye Hospital, Ningbo, China.. Electronic address: maojjhh@163.com.

Neuropeptides ; 82: 102057, 2020 Aug.

Article in En | MEDLINE | ID: mdl-32461025

Subject(s)

Diabetic Retinopathy/metabolism; Ependymoglial Cells/metabolism; Glucose/administration & dosage; Inflammasomes/metabolism; Inflammation/metabolism; Nuclear Receptor Subfamily 4, Group A, Member 2/metabolism; Signal Transduction; Animals; Cell Line; Diabetes Mellitus, Experimental/chemically induced; Diabetes Mellitus, Experimental/metabolism; Glucose/metabolism; Humans; NF-kappa B/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Retinal Ganglion Cells; Streptozocin/administration & dosage; Up-Regulation

Key words

Diabetic retinopathy (DR); Müller cells; NACHT, LRR and PYD domain-containing protein 3 (NLRP3); Nuclear factor-kappa B (NF-κB); Nuclear receptor subfamily 4 group A member 2 (Nurr1)

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Diabetic Retinopathy / Nuclear Receptor Subfamily 4, Group A, Member 2 / Inflammasomes / Ependymoglial Cells / Glucose / Inflammation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2020 Type: Article

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