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Cancer cells display increased migration and deformability in pace with metastatic progression.
Liu, Zhenhui; Lee, Se Jong; Park, Seungman; Konstantopoulos, Konstantinos; Glunde, Kristine; Chen, Yun; Barman, Ishan.
Affiliation
  • Liu Z; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
  • Lee SJ; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
  • Park S; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
  • Konstantopoulos K; Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.
  • Glunde K; Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD, USA.
  • Chen Y; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
  • Barman I; Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.
FASEB J ; 34(7): 9307-9315, 2020 07.
Article in En | MEDLINE | ID: mdl-32463148
ABSTRACT
In this study, we explored the relation between metastatic states vs the capacity of confined migration, amoeboid transition, and cellular stiffness. We compared across an isogenic panel of human breast cancer cells derived from MDA-MB-231 cells. It was observed that cells after lung metastasis have the fastest migration and lowest stiffness, with a significantly higher capacity to transition into an amoeboid mode. Our findings illustrate that metastasis is a selective process favoring motile and softer cells. Moreover, the observation that circulating tumor cells resemble the parental cell line, but not lung-metastatic cells, suggests that cells with higher deformability and motility are likely selected during extravasation and colonization.
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Cell Movement / Epithelial-Mesenchymal Transition / Lung Neoplasms Limits: Female / Humans Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Cell Movement / Epithelial-Mesenchymal Transition / Lung Neoplasms Limits: Female / Humans Language: En Year: 2020 Type: Article