Salidroside protects against diabetes mellitus-induced kidney injury and renal fibrosis by attenuating TGF-ß1 and Wnt1/3a/ß-catenin signalling.

Shati, Ali A; Alfaifi, Mohammad Y

Shati, Ali A; Alfaifi, Mohammad Y.

Affiliation

Shati AA; Department of Biology, College of Science, King Khalid University (KKU), Abha, Saudi Arabia.
Alfaifi MY; Department of Biology, College of Science, King Khalid University (KKU), Abha, Saudi Arabia.

Clin Exp Pharmacol Physiol ; 47(10): 1692-1704, 2020 10.

Article in En | MEDLINE | ID: mdl-32472701

Subject(s)

Diabetes Mellitus/pathology; Glucosides/pharmacology; Kidney/drug effects; Kidney/injuries; Phenols/pharmacology; Transforming Growth Factor beta1/metabolism; Wnt Signaling Pathway/drug effects; Animals; Fibronectins/metabolism; Fibrosis; Glucosides/therapeutic use; Kidney/metabolism; Kidney/pathology; Male; Phenols/therapeutic use; Rats

Key words

GS3Kß; Salidroside; TGF-ß1; Wnt/ß-catenin; diabetes mellitus; kidney; rats

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Full text: 1 Database: MEDLINE Main subject: Phenols / Diabetes Mellitus / Transforming Growth Factor beta1 / Wnt Signaling Pathway / Glucosides / Kidney Limits: Animals Language: En Year: 2020 Type: Article

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