Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight.

Riccardi, Claudia; Meyer, Albert; Vasseur, Jean-Jacques; Cavasso, Domenico; Russo Krauss, Irene; Paduano, Luigi; Morvan, François; Montesarchio, Daniela

Riccardi, Claudia; Meyer, Albert; Vasseur, Jean-Jacques; Cavasso, Domenico; Russo Krauss, Irene; Paduano, Luigi; Morvan, François; Montesarchio, Daniela.

Affiliation

Riccardi C; Department of Chemical Sciences, University of Naples Federico II, Via Cintia 21, I-80126 Naples, Italy.
Meyer A; Institut des Biomolécules Max Mousseron, Univ. Montpellier, CNRS, ENSCM, 34095 Montpellier, France.
Vasseur JJ; Institut des Biomolécules Max Mousseron, Univ. Montpellier, CNRS, ENSCM, 34095 Montpellier, France.
Cavasso D; Department of Chemical Sciences, University of Naples Federico II, Via Cintia 21, I-80126 Naples, Italy.
Russo Krauss I; Department of Chemical Sciences, University of Naples Federico II, Via Cintia 21, I-80126 Naples, Italy.
Paduano L; CSGI-Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Italy.
Morvan F; Department of Chemical Sciences, University of Naples Federico II, Via Cintia 21, I-80126 Naples, Italy.
Montesarchio D; CSGI-Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Italy.

Int J Mol Sci ; 21(11)2020 May 29.

Article in En | MEDLINE | ID: mdl-32485818

Subject(s)

Anticoagulants/chemical synthesis; Aptamers, Nucleotide/chemical synthesis; Circular Dichroism; Cycloaddition Reaction/methods; Fibrinogen/chemistry; G-Quadruplexes; Oximes/chemistry; Ultraviolet Rays

Key words

DNA aptamers; G-quadruplex; NU172; anticoagulant activity; biophysical characterization; cyclization; duplex/quadruplex; structure-activity relationship; thrombin

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