Topography of Cholinergic Changes in Dementia With Lewy Bodies and Key Neural Network Hubs.
J Neuropsychiatry Clin Neurosci
; 32(4): 370-375, 2020.
Article
in En
| MEDLINE
| ID: mdl-32498602
ABSTRACT
OBJECTIVES:
The authors investigated the topography of cholinergic vulnerability in patients with dementia with Lewy bodies (DLB) using positron emission tomography (PET) imaging with the vesicular acetylcholine transporter (VAChT) [18F]-fluoroethoxybenzovesamicol ([18F]-FEOBV) radioligand.METHODS:
Five elderly participants with DLB (mean age, 77.8 years [SD=4.2]) and 21 elderly healthy control subjects (mean age, 73.62 years [SD=8.37]) underwent clinical assessment and [18F]-FEOBV PET.RESULTS:
Compared with the healthy control group, reduced VAChT binding in patients with DLB demonstrated nondiffuse regionally distinct and prominent reductions in bilateral opercula and anterior cingulate to mid-cingulate cortices, bilateral insula, right (more than left) lateral geniculate nuclei, pulvinar, right proximal optic radiation, bilateral anterior and superior thalami, and posterior hippocampal fimbria and fornices.CONCLUSIONS:
The topography of cholinergic vulnerability in DLB comprises key neural hubs involved in tonic alertness (cingulo-opercular), saliency (insula), visual attention (visual thalamus), and spatial navigation (fimbria/fornix) networks. The distinct denervation pattern suggests an important cholinergic role in specific clinical disease-defining features, such as cognitive fluctuations, visuoperceptual abnormalities causing visual hallucinations, visuospatial changes, and loss of balance caused by DLB.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Thalamus
/
Acetylcholine
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Cerebral Cortex
/
Lewy Body Disease
/
Nerve Net
Type of study:
Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Limits:
Aged
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Aged80
/
Female
/
Humans
/
Male
Language:
En
Year:
2020
Type:
Article