Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics.

Bhagwan, Jamie R; Mosqueira, Diogo; Chairez-Cantu, Karolina; Mannhardt, Ingra; Bodbin, Sara E; Bakar, Mine; Smith, James G W; Denning, Chris

Bhagwan, Jamie R; Mosqueira, Diogo; Chairez-Cantu, Karolina; Mannhardt, Ingra; Bodbin, Sara E; Bakar, Mine; Smith, James G W; Denning, Chris.

Affiliation

Bhagwan JR; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD, UK. Electronic address: j.bhagwan@axolbio.com.
Mosqueira D; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD, UK. Electronic address: diogo.mosqueira@nottingham.ac.uk.
Chairez-Cantu K; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD, UK.
Mannhardt I; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, and DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Bodbin SE; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD, UK.
Bakar M; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD, UK.
Smith JGW; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD, UK; Faculty of Medicine and Health Sciences, Norwich Medical School, University of East Anglia,NR4 7UQ, UK.
Denning C; Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD, UK. Electronic address: chris.denning@nottingham.ac.uk.

J Mol Cell Cardiol ; 145: 43-53, 2020 08.

Article in En | MEDLINE | ID: mdl-32531470

Subject(s)

Cardiomyopathy, Hypertrophic/pathology; Cardiomyopathy, Hypertrophic/therapy; Models, Cardiovascular; Actins/genetics; Actins/metabolism; Arrhythmias, Cardiac/complications; Arrhythmias, Cardiac/genetics; Arrhythmias, Cardiac/physiopathology; Base Sequence; CRISPR-Associated Protein 9/metabolism; CRISPR-Cas Systems; Calcium/metabolism; Cardiac Myosins/genetics; Cardiac Myosins/metabolism; Cardiomyopathy, Hypertrophic/genetics; Cardiomyopathy, Hypertrophic/physiopathology; Cell Line; Cell Respiration; Gene Expression Regulation; Genes, Reporter; Humans; Induced Pluripotent Stem Cells/metabolism; Mutation/genetics; Myocardial Contraction; Myocytes, Cardiac/metabolism; Myosin Heavy Chains/genetics; Myosin Heavy Chains/metabolism; Optogenetics; Phenotype; Tissue Engineering

Key words

Disease modeling; Hypertrophic cardiomyopathy; Isogenic human pluripotent stem cell-derived cardiomyocytes; Mechanistic insight; Tailored therapeutics

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Full text: 1 Database: MEDLINE Main subject: Cardiomyopathy, Hypertrophic / Models, Cardiovascular Type of study: Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article

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