Differential Urinary Proteome Analysis for Predicting Prognosis in Type 2 Diabetes Patients with and without Renal Dysfunction.

Ahn, Hee-Sung; Kim, Jong Ho; Jeong, Hwangkyo; Yu, Jiyoung; Yeom, Jeonghun; Song, Sang Heon; Kim, Sang Soo; Kim, In Joo; Kim, Kyunggon

Ahn, Hee-Sung; Kim, Jong Ho; Jeong, Hwangkyo; Yu, Jiyoung; Yeom, Jeonghun; Song, Sang Heon; Kim, Sang Soo; Kim, In Joo; Kim, Kyunggon.

Affiliation

Ahn HS; Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
Kim JH; Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea.
Jeong H; Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, Korea.
Yu J; Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
Yeom J; Convergence Medicine Research Center, Asan Institute for Life Sciences, Seoul 05505, Korea.
Song SH; Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea.
Kim SS; Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea.
Kim IJ; Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea.
Kim K; Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.

Int J Mol Sci ; 21(12)2020 Jun 14.

Article in En | MEDLINE | ID: mdl-32545899

Subject(s)

Biomarkers/urine; Diabetes Mellitus, Type 2/urine; Diabetic Nephropathies/urine; Proteomics/methods; Urine/chemistry; Acid Phosphatase/urine; Adult; Aged; Calcium-Binding Proteins/urine; Case-Control Studies; Cathepsin A/urine; Chromatography, Liquid; Diabetes Mellitus, Type 2/complications; Diabetic Nephropathies/etiology; Extracellular Matrix Proteins/urine; Female; G(M2) Activator Protein/urine; Humans; Male; Mass Spectrometry; Middle Aged; Mucin-1/urine; Prognosis; Retrospective Studies; Support Vector Machine

Key words

diabetic kidney disease; kidney function; machine learning; mass spectrometry; proteomics; statistical clinical model; urine

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Full text: 1 Database: MEDLINE Main subject: Urine / Biomarkers / Proteomics / Diabetes Mellitus, Type 2 / Diabetic Nephropathies Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article

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