Development of an optical microfiber immunosensor for prostate specific antigen analysis using a high-order-diffraction long period grating.
Opt Express
; 28(11): 15783-15793, 2020 May 25.
Article
in En
| MEDLINE
| ID: mdl-32549415
ABSTRACT
Fiber-optic biosensors are of great interest to many bio/chemical sensing applications. In this study, we demonstrate a high-order-diffraction long period grating (HOD-LPG) for the detection of prostate specific antigen (PSA). A HOD-LPG with a period number of less than ten and an elongated grating pitch could realize a temperature-insensitive and bending-independent biosensor. The bio-functionalized HOD-LPG was capable of detecting PSA in phosphate buffered saline with concentrations ranging from 5 to 500 ng/ml and exhibited excellent specificity. A limit of detection of 9.9 ng/ml was achieved, which is promising for analysis of the prostate specific antigen.
Full text:
1
Database:
MEDLINE
Main subject:
Biosensing Techniques
/
Prostate-Specific Antigen
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Optical Fibers
/
Fiber Optic Technology
Limits:
Humans
Language:
En
Year:
2020
Type:
Article