Betacoronavirus; Coronavirus Infections/metabolism; Free Radicals/metabolism; Pandemics; Pneumonia, Viral/metabolism; Acetylcysteine/therapeutic use; Animals; Antioxidants/therapeutic use; Ascorbic Acid/therapeutic use; Azithromycin/administration & dosage; Azithromycin/pharmacology; Azithromycin/therapeutic use; COVID-19; Clinical Trials as Topic; Coronavirus Infections/complications; Coronavirus Infections/drug therapy; Cytokine Release Syndrome/etiology; Cytokine Release Syndrome/metabolism; Drug Therapy, Combination; Free Radicals/antagonists & inhibitors; Glutathione/therapeutic use; Humans; Hydroxychloroquine/administration & dosage; Hydroxychloroquine/pharmacology; Hydroxychloroquine/therapeutic use; Mice; Multiple Organ Failure/etiology; Multiple Organ Failure/prevention & control; NF-E2-Related Factor 2/agonists; Nitric Oxide/metabolism; Orthomyxoviridae Infections/metabolism; Oxidative Stress; Pneumonia, Viral/complications; Pneumonia, Viral/drug therapy; Reactive Oxygen Species/metabolism; SARS-CoV-2; Severe Acute Respiratory Syndrome/drug therapy; Severe Acute Respiratory Syndrome/metabolism; COVID-19 Drug Treatment

COVID-19; Cytokine storm; Free radicals; Nitric oxide; Superoxide