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Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring.
Lkhagvadorj, Khosbayar; Meyer, Karolin F; Verweij, Laura P; Kooistra, Wierd; Reinders-Luinge, Marjan; Dijkhuizen, Henk W; de Graaf, Inge A M; Plösch, Torsten; Hylkema, Machteld N.
Affiliation
  • Lkhagvadorj K; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
  • Meyer KF; GRIAC Research Institute, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
  • Verweij LP; Department of Pulmonology and Allergology, Mongolian National University of Medical Sciences , Ulaanbaatar, Mongolia.
  • Kooistra W; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
  • Reinders-Luinge M; GRIAC Research Institute, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
  • Dijkhuizen HW; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
  • de Graaf IAM; GRIAC Research Institute, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
  • Plösch T; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
  • Hylkema MN; GRIAC Research Institute, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
Epigenetics ; 15(12): 1370-1385, 2020 12.
Article in En | MEDLINE | ID: mdl-32573327
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Full text: 1 Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Tobacco Smoke Pollution / Aryl Hydrocarbon Hydroxylases / DNA Methylation / Cytochrome P450 Family 2 / Liver / Nicotine Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Pregnancy Language: En Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Tobacco Smoke Pollution / Aryl Hydrocarbon Hydroxylases / DNA Methylation / Cytochrome P450 Family 2 / Liver / Nicotine Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Pregnancy Language: En Year: 2020 Type: Article