Biological mechanisms underlying inter-individual variation in factor VIII clearance in haemophilia.

Turecek, Peter L; Johnsen, Jill M; Pipe, Steven W; O'Donnell, James S

Turecek, Peter L; Johnsen, Jill M; Pipe, Steven W; O'Donnell, James S.

Affiliation

Turecek PL; Baxalta Innovations GmbH, A Member of the Takeda Group of Companies, Vienna, Austria.
Johnsen JM; Bloodworks Northwest Research Institute, Seattle, WA, USA.
Pipe SW; Department of Medicine, University of Washington, Seattle, WA, USA.
O'Donnell JS; Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, MI, USA.

Haemophilia ; 26(4): 575-583, 2020 Jul.

Article in En | MEDLINE | ID: mdl-32596930

Subject(s)

Coagulants/pharmacokinetics; Factor VIII/pharmacokinetics; Hemophilia A/drug therapy; Metabolic Clearance Rate/physiology; von Willebrand Factor/metabolism; ABO Blood-Group System; Adolescent; Adult; Aged; Biological Variation, Population; Child; Child, Preschool; Coagulants/administration & dosage; Coagulants/therapeutic use; Factor VIII/administration & dosage; Factor VIII/therapeutic use; Half-Life; Hemophilia A/complications; Hemorrhage/etiology; Hemorrhage/prevention & control; Humans; Infusions, Intravenous; Male; Middle Aged; Young Adult

Key words

clearance; factor VIII; haemophilia A; pharmacokinetics; von Willebrand factor

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Factor VIII / Von Willebrand Factor / Coagulants / Metabolic Clearance Rate / Hemophilia A Type of study: Etiology_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Humans / Male / Middle aged Language: En Year: 2020 Type: Article

Fulltext

XML

PubMed Links

Search on Google