[Difficulties evaluating hematological response in patients with multiple myeloma and dialysis - dependent renal impairment].
Ter Arkh
; 91(7): 70-74, 2019 Jul 15.
Article
in Ru
| MEDLINE
| ID: mdl-32598738
ABSTRACT
AIM:
to determine serum free light chains (FLC) level by patients with multiple myeloma (MM) and dialysis - dependent renal impairment in which the amount Bence Jones (BJ) protein in the urine met the criteria of hematological response. PATIENTS ANDMETHODS:
This study included 13 MM with dialysis - dependent renal impairment patients (estimated glomerular filtration rate < 10 ml/min), whose urine BJ protein content was less than 200 mg/day after antimyeloma therapy (including 11 patients whose urine BJ protein content was less than 100 mg/day).RESULTS:
The median serum concentration of monoclonal FLC was 608.7 (298-8380) mg/l. Thus, with trace amounts BJ protein in the urine serum content monoclonal FLC varied 28 times with the same degree of severity of renal failure. In patients with oliguria serum SLC content was significantly higher than in normal diuresis (1109 and 307 mg/L; p.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Bence Jones Protein
/
Immunoglobulin Light Chains
/
Multiple Myeloma
Limits:
Humans
Language:
Ru
Year:
2019
Type:
Article