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JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma.
Manieri, Elisa; Folgueira, Cintia; Rodríguez, María Elena; Leiva-Vega, Luis; Esteban-Lafuente, Laura; Chen, Chaobo; Cubero, Francisco Javier; Barrett, Tamera; Cavanagh-Kyros, Julie; Seruggia, Davide; Rosell, Alejandro; Sanchez-Cabo, Fátima; Gómez, Manuel Jose; Monte, Maria J; G Marin, Jose J; Davis, Roger J; Mora, Alfonso; Sabio, Guadalupe.
Affiliation
  • Manieri E; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
  • Folgueira C; Department of Immunology and Oncology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.
  • Rodríguez ME; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
  • Leiva-Vega L; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
  • Esteban-Lafuente L; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
  • Chen C; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
  • Cubero FJ; Department of Immunology, Ophthalmology, and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.
  • Barrett T; Department of Immunology, Ophthalmology, and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.
  • Cavanagh-Kyros J; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
  • Seruggia D; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
  • Rosell A; Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.
  • Sanchez-Cabo F; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
  • Gómez MJ; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
  • Monte MJ; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
  • G Marin JJ; Laboratory of Experimental Hepatology and Drug Targeting, National Institute for Study of Liver and Gastrointestinal Diseases (CIBERehd), University of Salamanca, 37007 Salamanca, Spain.
  • Davis RJ; Laboratory of Experimental Hepatology and Drug Targeting, National Institute for Study of Liver and Gastrointestinal Diseases (CIBERehd), University of Salamanca, 37007 Salamanca, Spain.
  • Mora A; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605; roger.davis@umassmed.edu amora@cnic.es guadalupe.sabio@cnic.es.
  • Sabio G; Centro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain; roger.davis@umassmed.edu amora@cnic.es guadalupe.sabio@cnic.es.
Proc Natl Acad Sci U S A ; 117(28): 16492-16499, 2020 07 14.
Article in En | MEDLINE | ID: mdl-32601222
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Full text: 1 Database: MEDLINE Main subject: Bile Acids and Salts / Cholangiocarcinoma / Mitogen-Activated Protein Kinase 8 / Mitogen-Activated Protein Kinase 9 Limits: Animals / Humans / Male Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Bile Acids and Salts / Cholangiocarcinoma / Mitogen-Activated Protein Kinase 8 / Mitogen-Activated Protein Kinase 9 Limits: Animals / Humans / Male Language: En Year: 2020 Type: Article