Enhanced cytotoxicity and inhibition of DNA damage repair in irradiated murine L5178Y lymphoblasts and human chronic lymphocytic leukemia cells treated with 2'-deoxycoformycin and deoxyadenosine in vitro.

Begleiter, A; Pugh, L; Israels, L G; Johnston, J B

Begleiter, A; Pugh, L; Israels, L G; Johnston, J B.

Affiliation

Begleiter A; Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.

Cancer Res ; 48(14): 3981-6, 1988 Jul 15.

Article in En | MEDLINE | ID: mdl-3260129

Subject(s)

Coformycin/pharmacology; DNA Damage; DNA Repair; Deoxyadenosines/pharmacology; Leukemia L5178/genetics; Leukemia, Experimental/genetics; Leukemia, Lymphoid/genetics; Ribonucleosides/pharmacology; Adenosine Deaminase Inhibitors; Adenosine Triphosphate/metabolism; Animals; Coformycin/analogs & derivatives; Deoxyadenine Nucleotides/metabolism; Drug Synergism; Mice; NAD/metabolism; Pentostatin

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Database: MEDLINE Main subject: Ribonucleosides / DNA Damage / Leukemia, Experimental / Leukemia L5178 / Leukemia, Lymphoid / Coformycin / Deoxyadenosines / DNA Repair Type of study: Prognostic_studies Limits: Animals Language: En Year: 1988 Type: Article

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