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Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals.
van der Stel, Wanda; Carta, Giada; Eakins, Julie; Darici, Salihanur; Delp, Johannes; Forsby, Anna; Bennekou, Susanne Hougaard; Gardner, Iain; Leist, Marcel; Danen, Erik H J; Walker, Paul; van de Water, Bob; Jennings, Paul.
Affiliation
  • van der Stel W; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
  • Carta G; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan, 1108, 1081 HZ, Amsterdam, The Netherlands.
  • Eakins J; Cyprotex Discovery Ltd, Alderley Park, Macclesfield, Cheshire, UK.
  • Darici S; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
  • Delp J; University of Konstanz, Constance, Germany.
  • Forsby A; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Bennekou SH; National Food Institute Technical University of Denmark (DTU), Lyngby, Denmark.
  • Gardner I; Certara UK Limited, Sheffield, UK.
  • Leist M; University of Konstanz, Constance, Germany.
  • Danen EHJ; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
  • Walker P; Cyprotex Discovery Ltd, Alderley Park, Macclesfield, Cheshire, UK.
  • van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. water_b@lacdr.leidenuniv.nl.
  • Jennings P; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan, 1108, 1081 HZ, Amsterdam, The Netherlands. p.jennings@vu.nl.
Arch Toxicol ; 94(8): 2707-2729, 2020 08.
Article in En | MEDLINE | ID: mdl-32607615
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Full text: 1 Database: MEDLINE Main subject: Uncoupling Agents / Mitochondria, Liver / Agrochemicals / Hepatocytes / Electron Transport Chain Complex Proteins / Energy Metabolism / Kidney Tubules, Proximal Limits: Humans Language: En Year: 2020 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Uncoupling Agents / Mitochondria, Liver / Agrochemicals / Hepatocytes / Electron Transport Chain Complex Proteins / Energy Metabolism / Kidney Tubules, Proximal Limits: Humans Language: En Year: 2020 Type: Article