Ligustilide alleviates the insulin resistance, lipid accumulation, and pathological injury with elevated phosphorylated AMPK level in rats with diabetes mellitus.

Guo, Sujuan; Wang, Guofeng; Yang, Zhengxiong

Guo, Sujuan; Wang, Guofeng; Yang, Zhengxiong.

Affiliation

Guo S; Department of Endocrine, Lianyungang No. 1 People's Hospital High-Tech Zone, Lianyungang, China.
Wang G; Department of Endocrine, Lianyungang No. 1 People's Hospital High-Tech Zone, Lianyungang, China.
Yang Z; Department of Endocrine, Lianyungang No. 1 People's Hospital High-Tech Zone, Lianyungang, China.

J Recept Signal Transduct Res ; 41(1): 85-92, 2021 Feb.

Article in En | MEDLINE | ID: mdl-32643505

Subject(s)

4-Butyrolactone/analogs & derivatives; Diabetes Mellitus/drug therapy; NF-E2-Related Factor 2/genetics; Obesity/drug therapy; Protein Kinases/genetics; 4-Butyrolactone/pharmacology; AMP-Activated Protein Kinase Kinases; Animals; Blood Glucose/drug effects; Diabetes Mellitus/genetics; Diabetes Mellitus, Experimental/drug therapy; Diabetes Mellitus, Experimental/genetics; Diabetes Mellitus, Experimental/pathology; Diet, High-Fat/adverse effects; Humans; Insulin/metabolism; Insulin Resistance/genetics; Lipid Metabolism/drug effects; Liver/drug effects; Liver/metabolism; Liver/pathology; Obesity/genetics; Obesity/pathology; Phosphorylation/drug effects; Rats

Key words

AMPK; Ligustilide; diabetes mellitus; insulin resistance; lipid accumulation; pathological injury

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Full text: 1 Database: MEDLINE Main subject: Protein Kinases / 4-Butyrolactone / Diabetes Mellitus / NF-E2-Related Factor 2 / Obesity Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2021 Type: Article

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