Hypogammaglobulinemia in Adolescents and Young Adults with Acute Lymphoblastic Leukemia.
J Adolesc Young Adult Oncol
; 9(6): 687-692, 2020 12.
Article
in En
| MEDLINE
| ID: mdl-32668180
ABSTRACT
Hypogammaglobulinemia is a poorly described complication of chemotherapy in adolescents and young adults (AYAs, 15-39 years) with acute lymphoblastic leukemia (ALL). The majority of AYAs treated on a Berlin-Frankfurt-Munster-based ALL regimen experienced hypogammaglobulinemia (65.0% [13/20]). Febrile neutropenia episodes (throughout the treatment course) and infectious events during maintenance occurred more frequently in hypogammaglobulinemic patients compared with patients with normal immunoglobulin G levels (n = 7) (median 1.0 vs. 0.0, p = 0.02; 7.0 vs. 3.0, p = 0.02, respectively). Hypogammaglobulinemia did not impact overall or event-free survival. Further studies are needed to elucidate the etiology of hypogammaglobulinemia and to establish criteria for immunoglobulin replacement in these patients.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Agammaglobulinemia
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Limits:
Adolescent
/
Adult
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Female
/
Humans
/
Male
Language:
En
Year:
2020
Type:
Article