Life expectancy and cause of death in individuals with haemophilia A and B in Norway, 1986-2018.
Eur J Haematol
; 105(5): 608-615, 2020 Nov.
Article
in En
| MEDLINE
| ID: mdl-32710483
ABSTRACT
OBJECTIVES:
Evaluate trends over time in age- and cause of death in males with haemophilia (PWH) in Norway compared with the general male population and investigate its correlates with improvements in haemophilia treatment.METHODS:
Data about age and cause of death in the period of 1986-2018, from two independent, high-quality national registries the Norwegian Cause of Death Registry (NCoDR) and the patient registry at Centre for Rare Disorders (CRD), Oslo University Hospital.RESULTS:
Life expectancy increased significantly from 1986 to 2018. However, PWH still had a decreased mean age at death of 56.8 years (SD = 24.7) in the NCoDR and 58.6 years (SD = 21.7) in the CRD data, compared with 73.9 years (SD = 16.3) in the general male population. There was a distinct shift in the most frequently reported haemophilia-related causes of death, such as haemorrhage and AIDS, to more age-related causes of death, such as cancer, reflecting an ageing population.CONCLUSION:
Haemophilia treatment has improved significantly in the last three decades. Despite treatment-related improvements, PWH in Norway still have a decreased life expectancy compared with the general male population.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Life Expectancy
/
Hemophilia B
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Hemophilia A
/
Norway
Limits:
Adult
/
Aged
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Female
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Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Year:
2020
Type:
Article