Vitamin D insufficiency as a potential culprit in critical COVID-19 patients.
J Med Virol
; 93(2): 733-740, 2021 02.
Article
in En
| MEDLINE
| ID: mdl-32716073
ABSTRACT
BACKGROUND:
As an immune modulator, vitamin D has been implicated in the coronavirus disease-2019 (COVID-19) outcome. We aim to systematically explore the association of vitamin D serum levels with COVID-19 severity and prognosis.METHODS:
The standardized mean difference (SMD) or odds ratio and 95% confidence interval (CI) were applied to estimate pooled results from six studies. The prognostic performance of vitamin D serum levels for predicting adverse outcomes with detection of the best cutoff threshold was determined by receiver operating characteristic curve analysis. Decision tree analysis by combining vitamin D levels and clinical features was applied to predict severity in COVID-19 patients.RESULTS:
Mean vitamin D serum level of 376 patients, was 21.9 nmol/L (95% CI = 15.36-28.45). Significant heterogeneity was found (I2 = 99.1%, p < .001). Patients with poor prognosis (N = 150) had significantly lower serum levels of vitamin D compared with those with good prognosis (N = 161), representing an adjusted standardized mean difference of -0.58 (95% Cl = -0.83 to -0.34, p < .001).CONCLUSION:
Serum vitamin D levels could be implicated in the COVID-19 prognosis. Diagnosis of vitamin D deficiency could be a helpful adjunct in assessing patients' potential of developing severe COVID-19. Appropriate preventative and/or therapeutic intervention may improve COVID-19 outcomes.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Vitamin D
/
Vitamin D Deficiency
/
SARS-CoV-2
/
COVID-19
Type of study:
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2021
Type:
Article