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HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis.
Loiseau, Chloé; Brites, Daniela; Reinhard, Miriam; Zürcher, Kathrin; Borrell, Sonia; Ballif, Marie; Fenner, Lukas; Cox, Helen; Rutaihwa, Liliana K; Wilkinson, Robert J; Yotebieng, Marcel; Carter, E Jane; Abimiku, Alash'le; Marcy, Olivier; Gotuzzo, Eduardo; Avihingsanon, Anchalee; Zetola, Nicola; Doulla, Basra; Böttger, Erik C; Egger, Matthias; Gagneux, Sebastien.
Affiliation
  • Loiseau C; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Brites D; University of Basel, Basel, Switzerland.
  • Reinhard M; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Zürcher K; University of Basel, Basel, Switzerland.
  • Borrell S; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Ballif M; University of Basel, Basel, Switzerland.
  • Fenner L; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Cox H; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Rutaihwa LK; University of Basel, Basel, Switzerland.
  • Wilkinson RJ; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Yotebieng M; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Carter EJ; Institute of Infectious Disease and Molecular Medicine and Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa.
  • Abimiku A; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Marcy O; University of Basel, Basel, Switzerland.
  • Gotuzzo E; Ifakara Health Institute, Bagamoyo, Tanzania.
  • Avihingsanon A; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa.
  • Zetola N; Department of Infectious Diseases, Imperial College London, London, United Kingdom.
  • Doulla B; Francis Crick Institute, London, United Kingdom.
  • Böttger EC; Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Egger M; Department of Medicine, Moi University School of Medicine, and Moi Teaching and Referral Hospital, Eldoret, Kenya.
  • Gagneux S; Institute of Human Virology, Abuja, Nigeria.
Antimicrob Agents Chemother ; 64(10)2020 09 21.
Article in En | MEDLINE | ID: mdl-32718966
ABSTRACT
We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.
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Full text: 1 Database: MEDLINE Main subject: HIV Infections / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Type of study: Risk_factors_studies Limits: Humans Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: HIV Infections / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Type of study: Risk_factors_studies Limits: Humans Language: En Year: 2020 Type: Article