Exploration of the Electrophilic Reactivity of the Cytotoxic Marine Alkaloid Discorhabdin C and Subsequent Discovery of a New Dimeric C-1/N-13-Linked Discorhabdin Natural Product.

Lam, Cary F C; Cadelis, Melissa M; Copp, Brent R

Lam, Cary F C; Cadelis, Melissa M; Copp, Brent R.

Affiliation

Lam CFC; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Cadelis MM; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Copp BR; School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Mar Drugs ; 18(8)2020 Jul 31.

Article in En | MEDLINE | ID: mdl-32752009

Subject(s)

Antimalarials/chemistry; Antineoplastic Agents/chemistry; Heterocyclic Compounds, 4 or More Rings/chemistry; Marine Toxins/chemistry; Quinones/chemistry; Animals; Antimalarials/isolation & purification; Antimalarials/pharmacology; Antineoplastic Agents/isolation & purification; Antineoplastic Agents/pharmacology; Cell Survival/drug effects; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/pathology; Dimerization; HCT116 Cells; Heterocyclic Compounds, 4 or More Rings/isolation & purification; Heterocyclic Compounds, 4 or More Rings/pharmacology; Humans; Marine Toxins/isolation & purification; Marine Toxins/pharmacology; Molecular Structure; Plasmodium falciparum/drug effects; Porifera/chemistry; Quinones/isolation & purification; Quinones/pharmacology; Structure-Activity Relationship

Key words

alkaloid; antimalarial; discorhabdin; discorhabdin dimer; electrophilic reactivity; marine natural product

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Full text: 1 Database: MEDLINE Main subject: Quinones / Heterocyclic Compounds, 4 or More Rings / Marine Toxins / Antimalarials / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2020 Type: Article

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