Cytochrome P450-mediated drug interactions in COVID-19 patients: Current findings and possible mechanisms.

El-Ghiaty, Mahmoud A; Shoieb, Sherif M; El-Kadi, Ayman O S

El-Ghiaty, Mahmoud A; Shoieb, Sherif M; El-Kadi, Ayman O S.

Affiliation

El-Ghiaty MA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Shoieb SM; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
El-Kadi AOS; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada. Electronic address: aelkadi@ualberta.ca.

Med Hypotheses ; 144: 110033, 2020 Nov.

Article in En | MEDLINE | ID: mdl-32758877

Subject(s)

COVID-19 Drug Treatment; Cytochrome P-450 Enzyme System/chemistry; Drug Interactions; Aged; Animals; COVID-19/metabolism; Comorbidity; Cytokines/metabolism; Drug Monitoring; Humans; Inflammation; Interleukin-6/genetics; Liver/injuries; Liver/metabolism; Mice; Mice, Knockout; Treatment Outcome; Vulnerable Populations

Key words

COVID-19; Cytochrome P450; Cytokines; Drug interaction; Metabolism; Pharmacokinetics; SARS-CoV-2

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Full text: 1 Database: MEDLINE Main subject: Cytochrome P-450 Enzyme System / Drug Interactions / COVID-19 Drug Treatment Type of study: Diagnostic_studies / Guideline Limits: Aged / Animals / Humans Language: En Year: 2020 Type: Article

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