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Acute symptomatic seizures in cerebral venous thrombosis.
Lindgren, Erik; Silvis, Suzanne M; Hiltunen, Sini; Heldner, Mirjam R; Serrano, Fabiola; de Scisco, Michele; Zelano, Johan; Zuurbier, Susanna M; Sánchez van Kammen, Mayte; Mansour, Maryam; Aguiar de Sousa, Diana; Penas, Sara; Al-Asady, Saleem; Ekizoglu, Esme; Redfors, Petra; Ahmed, Awet; Yesilot, Nilufer; Ghiasian, Masoud; Barboza, Miguel A; Arnao, Valentina; Aridon, Paolo; Punter, Martin N M; Ferro, José M; Kleinig, Timothy; Arauz, Antonio; Tatlisumak, Turgut; Arnold, Marcel; Putaala, Jukka; Coutinho, Jonathan M; Jood, Katarina.
Affiliation
  • Lindgren E; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Silvis SM; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Hiltunen S; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Heldner MR; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Serrano F; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • de Scisco M; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Zelano J; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Zuurbier SM; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Sánchez van Kammen M; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Mansour M; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Aguiar de Sousa D; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Penas S; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Al-Asady S; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Ekizoglu E; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Redfors P; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Ahmed A; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Yesilot N; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Ghiasian M; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Barboza MA; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Arnao V; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Aridon P; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Punter MNM; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Ferro JM; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Kleinig T; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Arauz A; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Tatlisumak T; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Arnold M; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Putaala J; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Coutinho JM; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
  • Jood K; From the Department of Clinical Neuroscience (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Department of Neurology (E.L., J.Z., P.R., A. Ahmed, T.T., K.J.), Sahlgrenska University Hospital, Gothenburg, Sweden; Dep
Neurology ; 95(12): e1706-e1715, 2020 09 22.
Article in En | MEDLINE | ID: mdl-32759191
OBJECTIVE: To identify characteristics, predictors, and outcomes of acute symptomatic seizures (ASS) in cerebral venous thrombosis (CVT), we investigated 1,281 consecutive adult patients with CVT included from 12 hospitals within the International CVT Consortium. METHODS: We defined ASS as any seizure between symptom onset and 7 days after diagnosis of CVT. We stratified ASS into prediagnosis and solely postdiagnosis ASS. Status epilepticus (SE) was also analyzed separately. We analyzed predictors for ASS and the association between ASS and clinical outcome (modified Rankin Scale) with multivariable logistic regression. RESULTS: Of 1,281 eligible patients, 441 (34%) had ASS. Baseline predictors for ASS were intracerebral hemorrhage (ICH; adjusted odds ratio [aOR] 4.1, 95% confidence interval [CI] 3.0-5.5), cerebral edema/infarction without ICH (aOR 2.8, 95% CI 2.0-4.0), cortical vein thrombosis (aOR 2.1, 95% CI 1.5-2.9), superior sagittal sinus thrombosis (aOR 2.0, 95% CI 1.5-2.6), focal neurologic deficit (aOR 1.9, 95% CI 1.4-2.6), sulcal subarachnoid hemorrhage (aOR 1.6, 95% CI 1.1-2.5), and female-specific risk factors (aOR 1.5, 95% CI 1.1-2.1). Ninety-three (7%) patients had solely postdiagnosis ASS, best predicted by cortical vein thrombosis (positive/negative predictive value 22%/92%). Eighty (6%) patients had SE, independently predicted by ICH, focal neurologic deficits, and cerebral edema/infarction. Neither ASS nor SE was independently associated with outcome. CONCLUSION: ASS occurred in one-third of patients with CVT and was associated with brain parenchymal lesions and thrombosis of the superficial system. In the absence of prediagnosis ASS, no subgroup was identified with sufficient risk of postdiagnosis ASS to justify prophylactic antiepileptic drug treatment. We found no association between ASS and outcome.
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Full text: 1 Database: MEDLINE Main subject: Seizures / Venous Thrombosis / Intracranial Thrombosis Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Seizures / Venous Thrombosis / Intracranial Thrombosis Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Year: 2020 Type: Article