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Functional characterization of a PROTAC directed against BRAF mutant V600E.
Posternak, Ganna; Tang, Xiaojing; Maisonneuve, Pierre; Jin, Ting; Lavoie, Hugo; Daou, Salima; Orlicky, Stephen; Goullet de Rugy, Theo; Caldwell, Lauren; Chan, Kin; Aman, Ahmed; Prakesch, Michael; Poda, Gennady; Mader, Pavel; Wong, Cassandra; Maier, Stefan; Kitaygorodsky, Julia; Larsen, Brett; Colwill, Karen; Yin, Zhe; Ceccarelli, Derek F; Batey, Robert A; Taipale, Mikko; Kurinov, Igor; Uehling, David; Wrana, Jeff; Durocher, Daniel; Gingras, Anne-Claude; Al-Awar, Rima; Therrien, Marc; Sicheri, Frank.
Affiliation
  • Posternak G; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Tang X; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Maisonneuve P; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Jin T; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Lavoie H; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Daou S; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Quebec, Montreal, Canada.
  • Orlicky S; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Quebec, Montreal, Canada.
  • Goullet de Rugy T; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Caldwell L; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Chan K; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Aman A; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Prakesch M; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Poda G; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Mader P; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Wong C; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Maier S; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Kitaygorodsky J; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Larsen B; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Colwill K; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Yin Z; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Ceccarelli DF; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Batey RA; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Taipale M; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Kurinov I; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Uehling D; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Wrana J; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
  • Durocher D; Center for Molecular, Cell and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Gingras AC; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Al-Awar R; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Therrien M; Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.
  • Sicheri F; Department of Chemistry and Chemical Biology, Cornell University, NE-CAT, Argonne, IL, USA.
Nat Chem Biol ; 16(11): 1170-1178, 2020 11.
Article in En | MEDLINE | ID: mdl-32778845
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Full text: 1 Database: MEDLINE Main subject: Thalidomide / Ubiquitin / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2020 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Thalidomide / Ubiquitin / Proto-Oncogene Proteins B-raf / Protein Kinase Inhibitors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2020 Type: Article