Synthesis of 5-Cyanomethyluridine (cnm<sup>5</sup> U) and 5-Cyanouridine (cn<sup>5</sup> U) Phosphoramidites and Their Incorporation into RNA Oligonucleotides.

Mao, Song; Tsai, Hsu-Chun; Sheng, Jia

Synthesis of 5-Cyanomethyluridine (cnm⁵ U) and 5-Cyanouridine (cn⁵ U) Phosphoramidites and Their Incorporation into RNA Oligonucleotides.

Mao, Song; Tsai, Hsu-Chun; Sheng, Jia.

Affiliation

Mao S; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, New York.
Tsai HC; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, New York.
Sheng J; Department of Chemistry and The RNA Institute, University at Albany, State University of New York, Albany, New York.

Curr Protoc Nucleic Acid Chem ; 82(1): e114, 2020 09.

Article in En | MEDLINE | ID: mdl-32846053

Subject(s)

Cyanides/chemistry; Oligoribonucleotides/chemistry; Organophosphorus Compounds/chemical synthesis; Chromatography, Thin Layer; Oligoribonucleotides/chemical synthesis; Oligoribonucleotides/isolation & purification; Organophosphorus Compounds/chemistry; Proton Magnetic Resonance Spectroscopy; Solid-Phase Synthesis Techniques/methods; Spectrometry, Mass, Electrospray Ionization

Key words

cyano-modification; nucleic acids; phosphoramidite; solid phase synthesis

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Full text: 1 Database: MEDLINE Main subject: Oligoribonucleotides / Organophosphorus Compounds / Cyanides Type of study: Guideline Language: En Year: 2020 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Oligoribonucleotides / Organophosphorus Compounds / Cyanides Type of study: Guideline Language: En Year: 2020 Type: Article