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Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs.
Unger, Melissa S; Schumacher, Lena; Enzlein, Thomas; Weigt, David; Zamek-Gliszczynski, Maciej J; Schwab, Matthias; Nies, Anne T; Drewes, Gerard; Schulz, Sandra; Reinhard, Friedrich B M; Hopf, Carsten.
Affiliation
  • Unger MS; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany.
  • Schumacher L; Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
  • Enzlein T; Cellzome - a GlaxoSmithKline company, Meyerhofstr. 1, 69177 Heidelberg, Germany.
  • Weigt D; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany.
  • Zamek-Gliszczynski MJ; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany.
  • Schwab M; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, 68163 Mannheim, Germany.
  • Nies AT; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, 1250 S Collegeville Road, Collegeville, Pennsylvania 19426, United States.
  • Drewes G; Dr. Margarete Fischer-Bosch-Institute for Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany.
  • Schulz S; Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, 72076 Tuebingen, Germany.
  • Reinhard FBM; Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tuebingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.
  • Hopf C; Dr. Margarete Fischer-Bosch-Institute for Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany.
Anal Chem ; 92(17): 11851-11859, 2020 09 01.
Article in En | MEDLINE | ID: mdl-32867487
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Full text: 1 Database: MEDLINE Main subject: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Organic Anion Transporters Limits: Humans Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Organic Anion Transporters Limits: Humans Language: En Year: 2020 Type: Article