Manipulation of epithelial cell death pathways by Shigella.
EMBO J
; 39(17): e106202, 2020 09 01.
Article
in En
| MEDLINE
| ID: mdl-32869315
ABSTRACT
Shigella, a major cause of bacterial dysentery, knows when it is not wanted. To generate and maintain its niche within host cells, this unwelcome guest injects several dozen virulence factors via a type 3 secretion system (T3SS). In this issue, Ashida et al (2020) have elucidated the role of two such factors from Shigella flexneri-OspC1 and OspD3-that together counteract apoptotic and necroptotic death pathways in colonised epithelial cells. As a result, Shigella can replicate to high levels within the colonic epithelium, leading to the substantial epithelial damage in shigellosis and efficient bacterial release for faecal transmission.
Full text:
1
Database:
MEDLINE
Main subject:
Shigella
/
Dysentery, Bacillary
Limits:
Humans
Language:
En
Year:
2020
Type:
Article