Cathepsins/genetics; Gene Expression Regulation, Neoplastic/drug effects; Nanoparticles/administration & dosage; Neoplasms/drug therapy; Protease Inhibitors/pharmacology; Tumor-Associated Macrophages/drug effects; Antigen Presentation/drug effects; Antigen Presentation/genetics; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacokinetics; Azepines/chemical synthesis; Azepines/pharmacology; Cathepsins/antagonists & inhibitors; Cathepsins/metabolism; Dendritic Cells/drug effects; Dendritic Cells/immunology; Dendritic Cells/pathology; Dipeptides/chemical synthesis; Dipeptides/pharmacology; Drug Carriers/chemical synthesis; Drug Carriers/pharmacokinetics; Humans; Immunotherapy/methods; Leucine/analogs & derivatives; Leucine/chemical synthesis; Leucine/pharmacology; Molecular Targeted Therapy/methods; Neoplasms/genetics; Neoplasms/immunology; Neoplasms/pathology; Protease Inhibitors/chemical synthesis; Sulfones/chemical synthesis; Sulfones/pharmacology; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; T-Lymphocytes/pathology; Tumor Microenvironment/drug effects; Tumor Microenvironment/genetics; Tumor Microenvironment/immunology; Tumor-Associated Macrophages/immunology; Tumor-Associated Macrophages/pathology

M2 macrophage; T cell; antigen presentation; antigen presenting cell; cysteine cathepsin; cysteine protease; dendritic cell; extracellular matrix (ECM); immune suppression; nanoparticle; polarization; targeting; therapy; tumor associated macrophage; tumor microenvironment; tumor-associated macrophage (TAM)