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Advances in modelling gold nanoparticle radiosensitization using new Geant4-DNA physics models.
Engels, Elette; Bakr, Samer; Bolst, David; Sakata, Dousatsu; Li, Nan; Lazarakis, Peter; McMahon, Stephen J; Ivanchenko, Vladimir; Rosenfeld, Anatoly B; Incerti, Sébastien; Kyriakou, Ioanna; Emfietzoglou, Dimitris; Lerch, Michael L F; Tehei, Moeava; Corde, Stéphanie; Guatelli, Susanna.
Affiliation
  • Engels E; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
  • Bakr S; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.
  • Bolst D; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
  • Sakata D; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
  • Li N; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
  • Lazarakis P; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
  • McMahon SJ; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.
  • Ivanchenko V; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
  • Rosenfeld AB; Centre for Cancer Research and Cell Biology, Queens University, Belfast, United Kingdom, BT7 1NN.
  • Incerti S; Tomsk State University, Tomsk, Russia.
  • Kyriakou I; CERN, Espl. des Particules 1, 1211, Meyrin, Switzerland.
  • Emfietzoglou D; Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
  • Lerch MLF; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.
  • Tehei M; CNRS, UMR5797, Centre d'Etudes Nucléaires Bordeaux Gradignan (CENBG), Chemin du Solarium, Gradignan, France.
  • Corde S; Université de Bordeaux, Centre d'Etudes Nucléaires Bordeaux Gradignan (CENBG), Chemin du Solarium, Gradignan, France.
  • Guatelli S; Medical Physics Laboratory, Dept. of Medicine, University of Ioannina, 45110, Ioannina, Greece.
Phys Med Biol ; 65(22): 225017, 2020 11 17.
Article in En | MEDLINE | ID: mdl-32916674
ABSTRACT
Gold nanoparticles have demonstrated significant radiosensitization of cancer treatment with x-ray radiotherapy. To understand the mechanisms at the basis of nanoparticle radiosensitization, Monte Carlo simulations are used to investigate the dose enhancement, given a certain nanoparticle concentration and distribution in the biological medium. Earlier studies have ordinarily used condensed history physics models to predict nanoscale dose enhancement with nanoparticles. This study uses Geant4-DNA complemented with novel track structure physics models to accurately describe electron interactions in gold and to calculate the dose surrounding gold nanoparticle structures at nanoscale level. The computed dose in silico due to a clinical kilovoltage beam and the presence of gold nanoparticles was related to in vitro brain cancer cell survival using the local effect model. The comparison of the simulation results with radiobiological experimental measurements shows that Geant4-DNA and local effect model can be used to predict cell survival in silico in the case of x-ray kilovoltage beams.
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Full text: 1 Database: MEDLINE Main subject: Radiation-Sensitizing Agents / Monte Carlo Method / Metal Nanoparticles / Gold / Models, Biological Type of study: Health_economic_evaluation / Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Radiation-Sensitizing Agents / Monte Carlo Method / Metal Nanoparticles / Gold / Models, Biological Type of study: Health_economic_evaluation / Prognostic_studies Limits: Humans Language: En Year: 2020 Type: Article