In Vitro and In Vivo Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of Leishmania amazonensis.
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Article
in En
| MEDLINE
| ID: mdl-32928731
ABSTRACT
Phenotypic assay against Leishmania amazonensisin vitro and in vivo led to identification of an adamantyl-based phenyl sulfonyl acetamide (compound 1) as a promising antileishmanial agent. Compound 1 inhibited the growth of intracellular forms of L. amazonensis (50% inhibitory concentration [IC50] = 4 µM) and exhibited low toxicity to host cells, with a selectivity index (SI) of >125. However, in a cutaneous leishmaniasis (CL) mouse model, compound 1 did not reduce lesions and parasite load when administered as monotherapy or when given simultaneously with a suboptimal dose of miltefosine.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Leishmania mexicana
/
Leishmaniasis, Cutaneous
/
Leishmania
/
Antiprotozoal Agents
Limits:
Animals
Language:
En
Year:
2020
Type:
Article