Adoptive transfer of CX3CR1 transduced-T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression.

Bonacina, Fabrizia; Martini, Elisa; Svecla, Monika; Nour, Jasmine; Cremonesi, Marco; Beretta, Giangiacomo; Moregola, Annalisa; Pellegatta, Fabio; Zampoleri, Veronica; Catapano, Alberico Luigi; Kallikourdis, Marinos; Norata, Giuseppe Danilo

Adoptive transfer of CX3CR1 transduced-T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression.

Bonacina, Fabrizia; Martini, Elisa; Svecla, Monika; Nour, Jasmine; Cremonesi, Marco; Beretta, Giangiacomo; Moregola, Annalisa; Pellegatta, Fabio; Zampoleri, Veronica; Catapano, Alberico Luigi; Kallikourdis, Marinos; Norata, Giuseppe Danilo.

Affiliation

Bonacina F; Department of Excellence of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Martini E; Adaptive Immunity Lab, Humanitas Clinical and Research Center, Rozzano-IRCCS, Milan, Italy.
Svecla M; Department of Excellence of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Nour J; Department of Excellence of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Cremonesi M; Adaptive Immunity Lab, Humanitas Clinical and Research Center, Rozzano-IRCCS, Milan, Italy.
Beretta G; Department of Environmental Science and Policy, Università degli Studi di Milano, Milan, Italy.
Moregola A; Department of Excellence of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Pellegatta F; IRCCS Multimedica, Milan, Italy.
Zampoleri V; Department of Excellence of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Catapano AL; Centro SISA per lo Studio dell'Aterosclerosi, Ospedale Bassini, Cinisello Balsamo, Italy.
Kallikourdis M; Department of Excellence of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.
Norata GD; IRCCS Multimedica, Milan, Italy.

Cardiovasc Res ; 117(9): 2069-2082, 2021 07 27.

Article in En | MEDLINE | ID: mdl-32931583

Subject(s)

Adoptive Transfer; Aortic Diseases/prevention & control; Atherosclerosis/prevention & control; CX3C Chemokine Receptor 1/metabolism; Genetic Therapy; Plaque, Atherosclerotic; T-Lymphocytes, Regulatory/transplantation; Transduction, Genetic; Adult; Animals; Aortic Diseases/immunology; Aortic Diseases/metabolism; Aortic Diseases/pathology; Atherosclerosis/immunology; Atherosclerosis/metabolism; Atherosclerosis/pathology; CX3C Chemokine Receptor 1/genetics; Cells, Cultured; Disease Models, Animal; Disease Progression; Female; Humans; Hyperlipoproteinemia Type II/immunology; Hyperlipoproteinemia Type II/metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Prospective Studies; Receptors, LDL/genetics; Receptors, LDL/metabolism; Retrospective Studies; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/metabolism

Key words

Atherosclerosis; Cellular therapy; Tregulatory cells

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Full text: 1 Database: MEDLINE Main subject: Aortic Diseases / Transduction, Genetic / Genetic Therapy / T-Lymphocytes, Regulatory / Adoptive Transfer / Atherosclerosis / Plaque, Atherosclerotic / CX3C Chemokine Receptor 1 Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Year: 2021 Type: Article

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