Sappanone A Prevents Left Ventricular Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model.
Int J Mol Sci
; 21(18)2020 Sep 21.
Article
in En
| MEDLINE
| ID: mdl-32967328
ABSTRACT
The incidence of myocardial infarction, among the causes of cardiovascular morbidity and mortality, is increasing globally. In this study, left ventricular (LV) dysfunction, including LV systolic and diastolic function, was investigated in a rat myocardial ischemia/reperfusion injury model with echocardiography. The homoisoflavanone sappanone A is known for its anti-inflammatory effects. Using echocardiography, we found that sappanone A administration significantly improved LV systolic and diastolic function in a rat myocardial ischemia/reperfusion injury model, especially in the early phase development of myocardial infarction. Based on myocardial infarct size, serum cardiac marker assay, and histopathological evaluation, sappanone A showed higher efficacy at the doses used in our experiments than curcumin and was evaluated for its potential to improve LV function.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Myocardial Reperfusion Injury
/
Ventricular Dysfunction, Left
/
Isoflavones
Limits:
Animals
Language:
En
Year:
2020
Type:
Article