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Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
Tortorici, M Alejandra; Beltramello, Martina; Lempp, Florian A; Pinto, Dora; Dang, Ha V; Rosen, Laura E; McCallum, Matthew; Bowen, John; Minola, Andrea; Jaconi, Stefano; Zatta, Fabrizia; De Marco, Anna; Guarino, Barbara; Bianchi, Siro; Lauron, Elvin J; Tucker, Heather; Zhou, Jiayi; Peter, Alessia; Havenar-Daughton, Colin; Wojcechowskyj, Jason A; Case, James Brett; Chen, Rita E; Kaiser, Hannah; Montiel-Ruiz, Martin; Meury, Marcel; Czudnochowski, Nadine; Spreafico, Roberto; Dillen, Josh; Ng, Cindy; Sprugasci, Nicole; Culap, Katja; Benigni, Fabio; Abdelnabi, Rana; Foo, Shi-Yan Caroline; Schmid, Michael A; Cameroni, Elisabetta; Riva, Agostino; Gabrieli, Arianna; Galli, Massimo; Pizzuto, Matteo S; Neyts, Johan; Diamond, Michael S; Virgin, Herbert W; Snell, Gyorgy; Corti, Davide; Fink, Katja; Veesler, David.
Affiliation
  • Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Beltramello M; Institut Pasteur and CNRS UMR 3569, Unité de Virologie Structurale, Paris, France.
  • Lempp FA; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Pinto D; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Dang HV; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Rosen LE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • McCallum M; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Bowen J; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Minola A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Jaconi S; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Zatta F; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • De Marco A; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Guarino B; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Bianchi S; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Lauron EJ; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Tucker H; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Zhou J; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Peter A; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Havenar-Daughton C; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Wojcechowskyj JA; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Case JB; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Chen RE; Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Kaiser H; Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Montiel-Ruiz M; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Meury M; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Czudnochowski N; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Spreafico R; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Dillen J; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Ng C; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Sprugasci N; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Culap K; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Benigni F; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Abdelnabi R; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Foo SC; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium.
  • Schmid MA; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium.
  • Cameroni E; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Riva A; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Gabrieli A; III Division of Infectious Diseases, Luigi Sacco University Hospital, University of Milan, Italy.
  • Galli M; III Division of Infectious Diseases, Luigi Sacco University Hospital, University of Milan, Italy.
  • Pizzuto MS; III Division of Infectious Diseases, Luigi Sacco University Hospital, University of Milan, Italy.
  • Neyts J; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
  • Diamond MS; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium.
  • Virgin HW; Departments of Medicine, Molecular Microbiology, Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Snell G; Vir Biotechnology, San Francisco, CA 94158, USA.
  • Corti D; Washington University School of Medicine, St. Louis, MO, USA.
  • Fink K; UTSouthwestern Medical Center, Dallas, TX, USA.
  • Veesler D; Vir Biotechnology, San Francisco, CA 94158, USA.
Science ; 370(6519): 950-957, 2020 11 20.
Article in En | MEDLINE | ID: mdl-32972994
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Full text: 1 Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Peptidyl-Dipeptidase A / Antibodies, Neutralizing / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus / Antibodies, Viral Limits: Animals / Humans Language: En Year: 2020 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Peptidyl-Dipeptidase A / Antibodies, Neutralizing / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus / Antibodies, Viral Limits: Animals / Humans Language: En Year: 2020 Type: Article