Low immune response rate of HIV-infected patients to a single injection of hepatitis A vaccine.
Infect Dis Now
; 51(1): 94-96, 2021 02.
Article
in En
| MEDLINE
| ID: mdl-33022294
ABSTRACT
OBJECTIVES:
We aimed to evaluate the immune response of HIV-1 positive patients to a single injection of HAV vaccine in a context of vaccine shortage during the 2017 European outbreak.METHODS:
We retrospectively enrolled all HIV-1 positive patients vaccinated by a single injection of HAV vaccine Vaqta 50®. HAV serology was performed before and>30 days after the vaccine injection.RESULTS:
Among the 73 patients, HIV-1 viral load was≤50 copies/mL in 93.2% of the cases. Medians of CD4 and median ratio of T CD4/CD8 cells were 658/mm3 and 0.9, respectively. A low immune response rate (59.7%) was observed among the patients. Responders had a significantly higher CD4/CD8 cell ratio than non-responders.CONCLUSIONS:
A serologic control should be recommended in this population in the event of a single injection vaccination schedule. During routine follow-up, and prior to any untoward event, physicians should assess the vaccination coverage of HIV-infected patients.Key words
Full text:
1
Database:
MEDLINE
Main subject:
HIV Infections
/
Hepatitis A Vaccines
/
Hepatitis A
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Middle aged
Language:
En
Year:
2021
Type:
Article