Bioactive compounds from Physalis angulata and their anti-inflammatory and cytotoxic activities.
J Asian Nat Prod Res
; 23(8): 809-817, 2021 Aug.
Article
in En
| MEDLINE
| ID: mdl-33030034
ABSTRACT
A new compound, physalucoside A (1), together with seven withanolides (2-8) and three flavonoids (9-11), were isolated from Physalis angulata L. (Solanaceae), a medicinal plant native to Vietnam. The chemical structures of these compounds were elucidated by one- and two-dimensional NMR spectra, high-resolution electrospray ionization mass spectrometry analyses, and chemical reactivity. The anti-inflammatory and cytotoxic activities of isolated compounds were also evaluated. These data suggest that the anti-inflammatory activity of P. angulata is due primarily to its withanolide content. This study demonstrates the potential of withanolides as promising candidates for the development of new anti-inflammatory drugs.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Physalis
/
Withanolides
Country/Region as subject:
Asia
Language:
En
Year:
2021
Type:
Article