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Centrally administered orexin prevents lipopolysaccharide and colchicine induced lethality via the vagal cholinergic pathway in a sepsis model in rats.
Igarashi, Sho; Nozu, Tsukasa; Ishioh, Masatomo; Kumei, Shima; Saito, Takeshi; Toki, Yasumichi; Hatayama, Mayumi; Yamamoto, Masayo; Shindo, Motohiro; Tanabe, Hiroki; Okumura, Toshikatsu.
Affiliation
  • Igarashi S; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
  • Nozu T; Department of Regional Medicine and Education, Asahikawa Medical University, Japan.
  • Ishioh M; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan; Department of General Medicine, Asahikawa Medical University, Japan.
  • Kumei S; Department of General Medicine, Asahikawa Medical University, Japan.
  • Saito T; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
  • Toki Y; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
  • Hatayama M; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
  • Yamamoto M; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
  • Shindo M; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
  • Tanabe H; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan.
  • Okumura T; Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan; Department of General Medicine, Asahikawa Medical University, Japan. Electronic address: okumurat@asahikawa-med.ac.jp.
Biochem Pharmacol ; 182: 114262, 2020 12.
Article in En | MEDLINE | ID: mdl-33035510
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Full text: 1 Database: MEDLINE Main subject: Vagus Nerve / Colchicine / Lipopolysaccharides / Sepsis / Cholinergic Neurons / Orexins Type of study: Prognostic_studies Limits: Animals Language: En Year: 2020 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Vagus Nerve / Colchicine / Lipopolysaccharides / Sepsis / Cholinergic Neurons / Orexins Type of study: Prognostic_studies Limits: Animals Language: En Year: 2020 Type: Article