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Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer.
Ashraf-Uz-Zaman, Md; Shahi, Sadisna; Akwii, Racheal; Sajib, Md Sanaullah; Farshbaf, Mohammad Jodeiri; Kallem, Raja Reddy; Putnam, William; Wang, Wei; Zhang, Ruiwen; Alvina, Karina; Trippier, Paul C; Mikelis, Constantinos M; German, Nadezhda A.
Affiliation
  • Ashraf-Uz-Zaman M; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
  • Shahi S; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
  • Akwii R; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
  • Sajib MS; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
  • Farshbaf MJ; Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA.
  • Kallem RR; Clinical Pharmacology & Experimental Therapeutics Center, Texas Tech University Health Sciences Center, Dallas, TX, USA.
  • Putnam W; Clinical Pharmacology & Experimental Therapeutics Center, Texas Tech University Health Sciences Center, Dallas, TX, USA.
  • Wang W; College of Pharmacy, University of Houston, Houston, TX, USA.
  • Zhang R; College of Pharmacy, University of Houston, Houston, TX, USA.
  • Alvina K; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX, USA; Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA.
  • Trippier PC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA; UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, NE, USA.
  • Mikelis CM; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
  • German NA; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA; Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX, USA. Electronic address: nadezhd
Eur J Med Chem ; 209: 112866, 2021 Jan 01.
Article in En | MEDLINE | ID: mdl-33039722
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Full text: 1 Database: MEDLINE Main subject: Urea / Receptor, Fibroblast Growth Factor, Type 1 / Triple Negative Breast Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2021 Type: Article
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Urea / Receptor, Fibroblast Growth Factor, Type 1 / Triple Negative Breast Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2021 Type: Article